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L-Tyrosine
| Product Name | L-Tyrosine |
| Price: | $12 / 20mg |
| Catalog No.: | CN00083 |
| CAS No.: | 60-18-4 |
| Molecular Formula: | C9H11NO3 |
| Molecular Weight: | 181.19 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)[C@H](Cc1ccc(cc1)O)N |
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| Description | L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex. |
| Target | Human Endogenous Metabolite |
| In Vitro | Results show that L-Tyrosine in vitro inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM), hippocampus (1.0, 2.0 and 4.0 mM), striatum (4.0 mM) and liver (0.1, 1.0, 2.0 and 4.0 mM). When complex I activity is analyzed, inhibition is observed in hippocampus (4.0 mM). In addition to inhibition in the hippocampus, complex II also is inhibited in the posterior cortex (0.1, 1.0, 2.0 and 4.0 mM) and liver (1.0, 2.0 and 4.0 mM). For complex II–III, activity is not altered by L-Tyrosine, and complex IV activity has decreased in the posterior cortex (1.0, 2.0 and 4.0 mM) following treatment with L-Tyrosine[1]. |
| In Vivo | The acute administration of L-Tyrosine inhibits the activity of citrate synthase in the posterior cortex and liver; however, in the striatum, the activity is increased. The results also demonstrate that acute administration of L-Tyrosine inhibits malate dehydrogenase and complex II, II–III and IV of the mitochondrial respiratory chain activity in the posterior cortex and liver of rats. The succinate dehydrogenase enzyme and complex I activity are inhibited in the posterior cortex and increased in the striatum. Furthermore, energy metabolism in the hippocampus is not amended by an acute administration of L-Tyrosine[1]. |
| Animal Admin | The equivalent of 500 mg/kg body weight of free L-Tyrosine is intraperitoneally administered in 30-day-old rats. Controls receive in saline solution. About 1 h after injections, rats are killed by decapitation without anesthesia[1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 385.2±32.0 °C at 760 mmHg |
| Flash Point | 186.7±25.1 °C |
| Exact Mass | 181.073898 |
| PSA | 83.55000 |
| LogP | 0.38 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |