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Carnosol
| Product Name | Carnosol |
| Price: | $62 / 20mg |
| Catalog No.: | CN08877 |
| CAS No.: | 5957-80-2 |
| Molecular Formula: | C20H26O4 |
| Molecular Weight: | 330.42 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Rosmarinus officinalis L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=C1O[C@@H]2C[C@@H]3[C@@]1(CCCC3(C)C)c1c2cc(c(c1O)O)C(C)C |
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| Description | Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. |
| Target | IC50: 5.5 μM (RSK2)[1]. |
| In Vitro | It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1[1]. |
| In Vivo | Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged[1]. |
| Animal Admin | Mice[1] Mice are orally administrated Carnosol at 100 mg/kg or vehicle 5 times a week over a period of 31 days[1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 524.8±50.0 °C at 760 mmHg |
| Flash Point | 187.0±23.6 °C |
| Exact Mass | 330.183105 |
| PSA | 66.76000 |
| LogP | 3.71 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Storage condition | −20°C |