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Oxindole
| Product Name | Oxindole |
| Price: | Inquiry |
| Catalog No.: | CN01055 |
| CAS No.: | 59-48-3 |
| Molecular Formula: | C8H7NO |
| Molecular Weight: | 133.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Isatis indigotica |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=C1Cc2c(N1)cccc2 |
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| Description | Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. |
| In Vitro | Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold[1]. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities[2]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 312.8±45.0 °C at 760 mmHg |
| Flash Point | 190.0±18.0 °C |
| Exact Mass | 133.052765 |
| PSA | 29.10000 |
| LogP | 0.61 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Storage condition | Refrigerator |