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Pseurotin A
| Product Name | Pseurotin A |
| Price: | Inquiry |
| Catalog No.: | CN00899 |
| CAS No.: | 58523-30-1 |
| Molecular Formula: | C22H25NO8 |
| Molecular Weight: | 431.44 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The cultures of marine Bacillus sp. FS8D. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity[1][2][3]. |
| In Vitro | Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC50 value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner[3]. Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells[3]. Cell Viability Assay[3] Cell Line: BT-474 cells, T47D cells Concentration: 40-200 μM Incubation Time: 24-72 hours Result: Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC50 values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively). |
| In Vivo | Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity[3]. Animal Model: HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)[1] Dosage: 10 mg/kg Administration: P.o.; 7X/week, 30 days Result: Significantly suppressed the growth of BT474 tumors. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 751.5±60.0 °C at 760 mmHg |
| Flash Point | 408.3±32.9 °C |
| Exact Mass | 431.158020 |
| PSA | 142.39000 |
| LogP | 3.23 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |