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Kusunokinin
| Product Name | Kusunokinin |
| Price: | Inquiry |
| Catalog No.: | CN02876 |
| CAS No.: | 58311-20-9 |
| Molecular Formula: | C21H22O6 |
| Molecular Weight: | 370.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Cryst. |
| Source: | The roots of Daphne odora |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis[1]. |
| In Vitro | Kusunokinin ((-)-Kusunokinin; 0.625-10 µg/mL; 72 h) 抑制癌细胞的活力，对 MCF-7、HT-29、MDA-MB-468、SW-620、A-549 和 MDA-MB-231 细胞的 IC50 值分别为 3.08、3.59、3.98、5.75、5.77 和 7.86 µM[1]。 Cell Viability Assay[1] Cell Line: Cancer cells Concentration: 0.625, 1.25, 2.5, 5 and 10 µg/mL Incubation Time: 72 hours Result: Had anticancer activity and inhibited cancer cells growth. |
| In Vivo | Kusunokinin ((-)-Kusunokinin; 7 和 14 mg/kg; i.h.; 每周 3 次, 持续 2 周) 通过下调信号分子 (c-Src、PI3K、Akt 和 Erk1/2) 抑制 NMU 诱导的乳腺癌大鼠的肿瘤生长[1]。 Animal Model: Female Sprague Dawley rats (7 weeks of age)[1] Dosage: 7 and 14 mg/kg Administration: Subcutaneous injection, 3 times a week for 2 weeks Result: Inhibited the mammary tumor growth and decreased tumor volume. Down-regulated c-Src, Erk1/2 and PI3K proteins and decreased Akt proteins. Inhibited downstream molecules in the cell cycle (c-Myc, E2f-1, CDK1 and cyclin B1) and metastasis (E-cadherin, MMP-2 and MMP-9). |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 543.6±45.0 °C at 760 mmHg |
| Flash Point | 238.5±28.8 °C |
| Exact Mass | 370.141632 |
| LogP | 3.36 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |