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Inosine
| Product Name | Inosine |
| Price: | $15 / 20mg |
| Catalog No.: | CN01074 |
| CAS No.: | 58-63-9 |
| Molecular Formula: | C10H12N4O5 |
| Molecular Weight: | 268.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Beta vulgaris. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1[nH]cnc2=O |
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| Description | Inosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties. In vitro: Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] In vivo: The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] |
| Target | Human Endogenous Metabolite |
| Density | 2.1±0.1 g/cm3 |
| Boiling Point | 670.5±65.0 °C at 760 mmHg |
| Flash Point | 359.3±34.3 °C |
| Exact Mass | 268.080780 |
| PSA | 133.49000 |
| LogP | -1.91 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |