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Oligomycin A
| Product Name | Oligomycin A |
| Price: | Inquiry |
| Catalog No.: | CN00209 |
| CAS No.: | 579-13-5 |
| Molecular Formula: | C45H74O11 |
| Molecular Weight: | 791.06 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC[C@@H]1/C=C/C=C/C[C@H](C)[C@@H](O)[C@](C)(O)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@@H]([C@H]([C@@H](/C=C/C(=O)O[C@H]2[C@H]([C@@H](CC1)O[C@@]1(CC[C@H]([C@H](O1)C[C@@H](O)C)C)[C@@H]2C)C)C)O)C C45H74O11 |
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| Description | Oligomycin A, created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity. |
| Target | Ki: 1 μM (F0F1-ATPase)[1] |
| In Vitro | Oligomycin A is a mitochondrial F0F1-ATPase inhibitor with a Ki of 1 μM. Oligomycin A shows cytotoxic to the NCI-60 cell lines, with GI50 of 10 nM. Oligomycin A also inhibits the activity of Triton X-100-solubilized ATPase with a Ki of 0.1 μM. Furthermore, Oligomycin A has anti-fungal activity[1]. Oligomycin A (2.4 µM) inhibits the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), and also suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) as well as the concomitant peaks of O2 consumption and ATP levels[2]. |
| Cell Assay | Drug (Oligomycin A, etc.) dilutions are added to monolayer or suspension cells in 96 well plates in triplicate for varying times. MTT is then added to the wells at a final concentration of 0.5 mg/mL. Supernatant is removed after pelleting the reduced MTT crystals. The crystals are fully dissolved in 40 mM HCl in isopropanol. Plates are scanned on a microplate reader at 595 nm[1]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 886.3±65.0 °C at 760 mmHg |
| Flash Point | 252.0±27.8 °C |
| Exact Mass | 790.523132 |
| PSA | 180.05000 |
| LogP | 6.17 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Storage condition | −20°C |