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Rapanone
| Product Name | Rapanone |
| Price: | $234 / 10mg |
| Catalog No.: | CN05859 |
| CAS No.: | 573-40-0 |
| Molecular Formula: | C19H30O4 |
| Molecular Weight: | 322.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Quinones |
| Physical Desc.: | Powder |
| Source: | The herbs of Paederia scandens (Lour.) Merr |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CCCCCCCCCCCCCC1=C(O)C(=O)C=C(C1=O)O |
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| Description | Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM[1][2][3][4]. |
| Target | PLA2:2.6 μM (IC50) |
| In Vitro | Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively[1]. Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells[1]. Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction[1]. |
| In Vivo | Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice[4]. |
| Density | 1.099g/cm3 |
| Boiling Point | 457ºC at 760mmHg |
| Flash Point | 244.3ºC |
| Exact Mass | 322.21400 |
| PSA | 74.60000 |
| LogP | 5.09330 |