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Nauclefine
| Product Name | Nauclefine |
| Price: | Inquiry |
| Catalog No.: | CN00031 |
| CAS No.: | 57103-51-2 |
| Molecular Formula: | C18H13N3O |
| Molecular Weight: | 287.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Nauclea officinalis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway[1]. |
| In Vitro | Nauclefine (250 nM, 48 h) 可以抑制 HeLa 细胞活力，并诱导细胞凋亡，造成细胞 PDE3A 和 SLFN12 依赖性死亡。Nauclefine 可以结合 PDE3A，但不抑制其磷酸二酯酶活性，能够促进 PDE3A 和 SLFN12 之间的相互作用，并通过增加 SLFN12 的稳定性促进细胞死亡[1]。 |
| In Vivo | Nauclefine (5 mg/kg, intratumorally, once per day for 22 days) 在感染 HeLa 细胞的雌性裸鼠(Balb/c-nu)中，显著降低了HeLa-luc 细胞肿瘤的总体生长，特别是治疗第 6 天后肿瘤体积明显减小，且没有导致小鼠体重的任何降低。其对肿瘤生长的抑制依赖于 PDE3A 和 SLFN12 的表达[1]。 |
| Density | 1.46g/cm3 |
| Boiling Point | 616.8ºC at 760 mmHg |
| Flash Point | 326.8ºC |
| Exact Mass | 287.10600 |
| PSA | 50.68000 |
| LogP | 3.10090 |