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Aloperine
| Product Name | Aloperine |
| Price: | $28 / 20mg |
| Catalog No.: | CN00770 |
| CAS No.: | 56293-29-9 |
| Molecular Formula: | C15H24N2 |
| Molecular Weight: | 232.37 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Sophora alopecuroides L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C1CCC2N(C1)CC1CC2C=C2C1NCCC2 |
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| Description | Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1]. |
| In Vitro | Aloperine (1-20 mM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM,respectively[1]. Aloperine (1-20 mM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells[1]. Aloperine (20–100 mM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells[1]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 367.7±37.0 °C at 760 mmHg |
| Flash Point | 155.8±17.5 °C |
| Exact Mass | 232.193954 |
| PSA | 15.27000 |
| LogP | 3.21 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Storage condition | -20℃ |