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Saikogenin D
| Product Name | Saikogenin D |
| Price: | $277 / 5mg |
| Catalog No.: | CN07264 |
| CAS No.: | 5573-16-0 |
| Molecular Formula: | C30H48O4 |
| Molecular Weight: | 472.71 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Bupleurum chinense |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2]. |
| In Vitro | Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1]. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 607.4±55.0 °C at 760 mmHg |
| Flash Point | 252.4±26.1 °C |
| Exact Mass | 472.355255 |
| PSA | 80.92000 |
| LogP | 5.38 |
| Vapour Pressure | 0.0±3.9 mmHg at 25°C |