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Skullcapflavone II
| Product Name | Skullcapflavone II |
| Price: | $161 / 5mg |
| Catalog No.: | CN05087 |
| CAS No.: | 55084-08-7 |
| Molecular Formula: | C19H18O8 |
| Molecular Weight: | 374.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The roots of Scutellaria baicalensis Georgi |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cccc(c1c1cc(=O)c2c(o1)c(OC)c(c(c2O)OC)OC)O |
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| Description | Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. |
| In Vitro | Skullcapflavone II inhibits osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. Skullcapflavone II decreases reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency[2]. |
| In Vivo | Skullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways[3]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 636.9±55.0 °C at 760 mmHg |
| Flash Point | 230.9±25.0 °C |
| Exact Mass | 374.100159 |
| PSA | 107.59000 |
| LogP | 1.58 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |