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Acetylshikonin
| Product Name | Acetylshikonin |
| Price: | Inquiry |
| Catalog No.: | CN05895 |
| CAS No.: | 54984-93-9 |
| Molecular Formula: | C18H18O6 |
| Molecular Weight: | 330.33 g/mol |
| Purity: | >=98% |
| Type of Compound: | Quinones |
| Physical Desc.: | Powder |
| Source: | The roots of Lithosperraum erythrorhizon Sieb. et Zucc. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | DL-Acetylshikonin is a non-selective, reversible Cytochrome P450 inhibitor with IC50 values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities[1]. |
| Target | CYP2C8:1.4 μM (IC50) CYP2B6:2.0 μM (IC50) CYP3A:2.3 μM (IC50) CYP2C19:2.5 μM (IC50) CYP2D6:2.5 μM (IC50) CYP2E1:2.7 μM (IC50) CYP2C9:3.3 μM (IC50) CYP2J2:3.3 μM (IC50) CYP2A6:3.8 μM (IC50) CYP1A2:4.0 μM (IC50) |
| In Vitro | DL-Acetylshikonin 抑制 CYP3A 介导的睾酮 (testosterone) 和 Nifedipine (HY-B0284) 代谢，IC50 值分别为 5.2 μM 和 3.0 μM，表明其以不依赖底物的方式抑制 CYP3A 活性[1]。 DL-Acetylshikonin 不是一种时间依赖性抑制剂[1]。 |
| Exact Mass | 330.11000 |
| PSA | 100.90000 |
| LogP | 2.69120 |