Home
Products
Norswertianolin
| Product Name | Norswertianolin |
| Price: | $234 / 5mg |
| Catalog No.: | CN05715 |
| CAS No.: | 54954-12-0 |
| Molecular Formula: | C19H18O11 |
| Molecular Weight: | 422.34 g/mol |
| Purity: | >=98% |
| Type of Compound: | Xanthones |
| Physical Desc.: | Powder |
| Source: | The herbs of Swertia diluta |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2]. |
| Target | CSE[2] |
| In Vitro | Norswertianolin (3.125~50 μM; H9c2 cells) has the protective effects on H2O2-induced H9c2 cells. Norswertianolin significantly increases the transcription levels of HO-1 and GCLC in H9c2 cells[1]. Norswertianolin (0~150 μM; HepG2 cells) high concentration increases the CSE protein level[2]. |
| In Vivo | Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2]. Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2]. Animal Model: Male Sprague Dawley rats (10~12 weeks)[2] Dosage: 4.4 mg/kg/day Administration: S.c. Result: Improved CSE/H2S production. |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 833.7±65.0 °C at 760 mmHg |
| Flash Point | 300.4±27.8 °C |
| Exact Mass | 422.084900 |
| PSA | 190.28000 |
| LogP | -1.66 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |