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Product Name | Arborinine |
Price: | Inquiry |
Catalog No.: | CN00879 |
CAS No.: | 5489-57-6 |
Molecular Formula: | C16H15NO4 |
Molecular Weight: | 285.29 g/mol |
Purity: | >=98% |
Type of Compound: | Alkaloids |
Physical Desc.: | Powder |
Source: | The fruits of Uapaca togoensis. |
Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
SMILES: |
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Description | Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2]. |
Target | LSD1 |
In Vitro | Arborinine (0, 5, 15, 30 µM; 48 h) 增加 H3K4me1/2、H3K9me1/2、E-cad 蛋白的表达[1]。 Arborinine (20 µM) 降低 786O 细胞中 UBE2O 蛋白水平的表达[1]。 Arborinine (20 µM) 诱导细胞周期停滞在 S 期并抑制细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: 786O, A498, 769P, Caki1, OSRC2 cells Concentration: 0-100 µM Incubation Time: 48, 72 h Result: Showed antiproliferative activity with IC50s of 30.62, 39.09, 15.67, 31.42, 30.35 µM at 48 h, 20.92, 27.01, 14.94, 30.26, 17.37 µM at 72 h for 786O, A498, 769P, Caki1, OSRC2 cells, respectively. Western Blot Analysis[1] Cell Line: 786O cells Concentration: 0, 5, 15, 30 µM Incubation Time: 48 h Result: Increased the expression of H3K4me1/2 and H3K9me1/2 protein in a dose-dependent manner. Cell Cycle Analysis[1] Cell Line: 786O and A498 cells Concentration: 20 µM Incubation Time: Result: Induced increased population in S phase and decreased population in G1 phase, significantly inhibited both early and late apoptosis of ccRCC cells |
In Vivo | Arborinine (40、80 mg/kg;灌胃; 21 天) 在小鼠体内显示出抗肿瘤活性[2]。 Animal Model: BALB/c nude mice (SGC-7901 cells and SGC-7901/ADR cells)[2] Dosage: 40, 80 mg/kg Administration: P.o.; for 21 days Result: Inhibited the growth of tumors while unchanged the body weights. |
Density | 1.296g/cm3 |
Boiling Point | 508.4ºC at 760 mmHg |
Flash Point | 261.3ºC |
Exact Mass | 285.10000 |
PSA | 60.69000 |
LogP | 2.41450 |