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Isoginkgetin
| Product Name | Isoginkgetin |
| Price: | $139 / 10mg |
| Catalog No.: | CN05227 |
| CAS No.: | 548-19-6 |
| Molecular Formula: | C32H22O10 |
| Molecular Weight: | 566.51 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The leaves of Ginkgo biloba L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccc(cc1)c1cc(=O)c2c(o1)c(c(cc2O)O)c1cc(ccc1OC)c1cc(=O)c2c(o1)cc(cc2O)O |
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| Description | Isoginkgetin is a MMP-9 inhibitor, also a Pre-mRNA Splicing Inhibitor with IC 50 of 30 uM.target : MMP-9 [1], Pre-mRNA Splicing [2]IC 50: 30 u M (Pre-mRNA Splicing)In vitro: Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin is also quite effective in inhibiting the activities of Akt and MMP-9 in MDA-MB-231 breast carcinomas and B16F10 melanoma. Isoginkgetin treatment result in marked decrease in invasion of these cells. isoginkgetin inhibit activities of both Akt and NF-κB. Isoginkgetin markedly decrease MMP-9 expression and invasion through inhibition of this pathway. [1] Splicing inhibition is the mechanistic basis of the anti-tumor activity of isoginkgetin. [2] Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. [3] |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 843.6±65.0 °C at 760 mmHg |
| Flash Point | 280.2±27.8 °C |
| Exact Mass | 566.121277 |
| PSA | 159.80000 |
| LogP | 5.24 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Storage condition | -20°C |