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Desoxo-narchinol A
| Product Name | Desoxo-narchinol A |
| Price: | $936 / 5mg |
| Catalog No.: | CN09101 |
| CAS No.: | 53859-06-6 |
| Molecular Formula: | C12H16O2 |
| Molecular Weight: | 192.25 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The rhizomes and roots of Nardostachys chinensis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Desoxo-narchinol A is an orally active and potent anti-inflammatory agent. Desoxo-narchinol A can be isolated from the roots and rhizomes of Nardostachys jatamansi. Desoxo-narchinol A can be used for septic shock and inflammatory diseases research[1][2][3]. |
| In Vitro | Desoxo-narchinol A inhibits tissue injury and production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, in the liver and lung[2]. Desoxo-narchinol A (0-500 nM, 24 h) inhibits the production of inflammatory mediators, such as iNOS and its derivative NO, COX-2, PGE2, IL-1β, IL-6 and TNF-α and H3 protein acetylation in murine peritoneal macrophages[2]. Desoxo-narchinol A inhibits LPS-induced activation of p38 in murine macrophages[2]. |
| In Vivo | Desoxo-narchinol A (0-0.5 mg/kg, IP, once) dramatically reduced mortality in a murine LPS-induced endotoxin shock model[2]. Desoxo-narchinol A (50 mg/kg, PO, once) shows the oral bioavailability of 18.1% in rats and 28.4% in mice[3] |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 345.0±31.0 °C at 760 mmHg |
| Flash Point | 146.9±17.4 °C |
| Exact Mass | 192.115036 |
| LogP | 1.95 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Storage condition | 2-8℃ |