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(-)-Bicuculline methochloride
| Product Name | (-)-Bicuculline methochloride |
| Price: | Inquiry |
| Catalog No.: | CN01158 |
| CAS No.: | 53552-05-9 |
| Molecular Formula: | C21H20NO6.Cl |
| Molecular Weight: | 417.8 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The tubers of Corydalis ambigua |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | (-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1]. |
| Target | GABAA[1] |
| In Vivo | (-)-Bicuculline methochloride (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2]. Animal Model: Rat L5-SNL model[2] Dosage: 0.6 nmol/rat Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) Result: Attenuated the antiallodynic effect of Neurotropin. |
| Exact Mass | 417.09800 |
| PSA | 63.22000 |