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1,3,5-Trihydroxy-4-prenylxanthone
| Product Name | 1,3,5-Trihydroxy-4-prenylxanthone |
| Price: | Inquiry |
| Catalog No.: | CN05816 |
| CAS No.: | 53377-61-0 |
| Molecular Formula: | C18H16O5 |
| Molecular Weight: | 312.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Xanthones |
| Physical Desc.: | Yellow powder |
| Source: | The herbs of Cudrania tricuspidata |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | 1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities[2]. |
| Target | PDE5:3 μM (IC50) iNOS Na+/H+ Exchanger |
| In Vitro | 1,3,5-Trihydroxy-4-prenylxanthone（10-30 μM；18 小时）通过消除 IKK 磷酸化、IκB 降解和 NF-κB 核转位抑制 LPS 诱导的 iNOS 表达。 1,3,5-Trihydroxy-4-prenylxanthone 通过干扰 IRAK-1 的翻译后修饰来抑制 LPS 诱导的 iNOS 表达，从而阻断 TAK1 介导的 IKK 和 MAPK 信号转导激活，从而下调 NF-κB 和 AP-1 的激活[2]。 Western Blot Analysis[2] Cell Line: RAW264.7 macrophages Concentration: 10 μM, 20 μM and 30 μM Incubation Time: 18 hours Result: Showed suppression of LPS-induced iNOS expression. Suppressed the nuclear level of c-Fos and c-Jun (major components of activator protein-1, AP-1) and the phosphorylated level of upstream signal molecules, such as JNK and ERK. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 550.7±49.0 °C at 760 mmHg |
| Flash Point | 204.3±23.3 °C |
| Exact Mass | 312.099762 |
| PSA | 90.90000 |
| LogP | 3.26 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |