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Isogosferol
| Product Name | Isogosferol |
| Price: | Inquiry |
| Catalog No.: | CN06246 |
| CAS No.: | 53319-52-1 |
| Molecular Formula: | C16H14O5 |
| Molecular Weight: | 286.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Powder |
| Source: | The roots of Heracleum repula |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2[1]. |
| In Vitro | Isogosferol (100, 200 µM; 1+16 h) 降低 RAW 264.7 细胞中 LPS (HY-D1056) 刺激的 NO 表达[1]。 Isogosferol (0, 25, 50, 100, 200 µM; 1+16 h) 以剂量依赖性方式降低 LPS 刺激的 iNOS、COX-2 蛋白表达[1]。 Isogosferol (0, 25, 50, 100, 200 µM; 1+1 h) 以剂量依赖性方式降低 LPS 刺激的 NF-κB 和 pERK1/2 表达[1]。 Isogosferol (50, 100, 200 µM µM; 1+16 h) 减少 LPS 刺激的促炎细胞因子 IL-1β 的释放[1]。 Cell Viability Assay[1] Cell Line: RAW 264.7 cells Concentration: 100, 200 µM (stimulated with LPS (1 µg/mL)) Incubation Time: 1+16 Result: Remarkably down-regulated the LPS-stimulated NO expression with an IC50 of 148 μM and shows no effect on cell viability. Western Blot Analysis[1] Cell Line: 0, 25, 50, 100, 200 µM Concentration: 1+16 Incubation Time: 1+16 Result: Decreased the expression of iNOS, COX-2 protein in a dose-dependent manner. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 498.2±45.0 °C at 760 mmHg |
| Flash Point | 255.1±28.7 °C |
| Exact Mass | 286.084137 |
| PSA | 72.81000 |
| LogP | 2.33 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |