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Myosmine
| Product Name | Myosmine |
| Price: | Inquiry |
| Catalog No.: | CN00587 |
| CAS No.: | 532-12-7 |
| Molecular Formula: | C9H10N2 |
| Molecular Weight: | 146.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Equisetum hyemale L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | c1ccc(cn1)C1=NCCC1 |
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| Description | Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2]. |
| Target | Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1)[1] |
| In Vitro | Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine[2]. |
| In Vivo | Myosmine (0.001, 0.005, 0.5, and 50 micromol/kg; oral; in Wistar rats) causes a higher percentage of the radioactivity excreted in urine (86.2% and 88.9%) at the two lower doses (0.001 and 0.005 micromol/kg),as compared with the higher doses (0.5 and 50 micromol/kg), where only 77.8% and 75.4% of the dose is found in urine[2]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 244.7±22.0 °C at 760 mmHg |
| Flash Point | 101.8±22.3 °C |
| Exact Mass | 146.084396 |
| PSA | 25.25000 |
| LogP | -0.63 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Storage condition | 2-8°C |