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7-Methoxycoumarin
| Product Name | 7-Methoxycoumarin |
| Price: | $23 / 20mg |
| Catalog No.: | CN06155 |
| CAS No.: | 531-59-9 |
| Molecular Formula: | C10H8O3 |
| Molecular Weight: | 176.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Cryst. |
| Source: | The herbs of Citrus reticulata cv. Chachiensis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccc2c(c1)oc(=O)cc2 |
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| Description | Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect. |
| In Vitro | Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 µM. Herniarin (100 µM) also induces apoptosis in MCF-7 cells[1]. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 µg/mL cisplatin, Herniarin (80 µg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation[2]. |
| Cell Assay | Briefly, the cells are seeded (104 cells per well) onto flat-bottomed 96-well culture plates and allowed to grow 72 h after treatment with various concentration of auraptene, Herniarin, umbelliferone, and umbelliprenin. After removing the medium, MTT solution (5 mg/mL in PBS) is added and incubated for 4 h and the resulting formazan is solubilized with DMSO (100 mL). The absorption is measured at 570 nm (620 nm as a reference) in an ELISA reader[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 335.3±37.0 °C at 760 mmHg |
| Flash Point | 138.6±21.1 °C |
| Exact Mass | 176.047348 |
| PSA | 39.44000 |
| LogP | 1.78 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |