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Sinapic acid
| Product Name | Sinapic acid |
| Price: | $15 / 20mg |
| Catalog No.: | CN06894 |
| CAS No.: | 530-59-6 |
| Molecular Formula: | C11H12O5 |
| Molecular Weight: | 224.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenylpropanoids |
| Physical Desc.: | Powder |
| Source: | The leaves of Platycladus orientalis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(C=CC(=O)O)cc(c1O)OC |
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| Description | Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1], and also inhibits ACE-I activity[2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells[1]. Sinapinic acid shows antioxidant and antidiabetic activities[2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats[3]. |
| Target | HDAC:2.27 mM (IC50) ACE-I |
| In Vitro | Sinapinic acid acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1]. Sinapinic acid also inhibits ACE-I activity[2]. Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC50s of 0.91 ± 0.02 mM and 1.6 ± 0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells[1]. |
| In Vivo | Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats[3]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 403.4±40.0 °C at 760 mmHg |
| Flash Point | 158.6±20.8 °C |
| Exact Mass | 224.068466 |
| PSA | 75.99000 |
| LogP | 1.29 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |