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Euxanthone
| Product Name | Euxanthone |
| Price: | Inquiry |
| Catalog No.: | CN05817 |
| CAS No.: | 529-61-3 |
| Molecular Formula: | C13H8O4 |
| Molecular Weight: | 228.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Xanthones |
| Physical Desc.: | Powder |
| Source: | The roots of Polygala tenuifolia Willd. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering Autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3]. |
| In Vitro | Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。 Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。 Cell Migration Assay [1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Inhibited cell migration at 24 hr. Western Blot Analysis[1] Cell Line: Osteosarcoma (OS) cells Concentration: 10 μM, 20 μM Incubation Time: 24 h Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion. |
| In Vivo | 在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。 Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）治疗使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。 Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2] Dosage: 30 mg/kg, 60 mg/kg Administration: p.o.;once a day; for 7 days Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 472.6±45.0 °C at 760 mmHg |
| Flash Point | 191.1±22.2 °C |
| Exact Mass | 228.042252 |
| PSA | 70.67000 |
| LogP | 1.92 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |