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Eudesmin
| Product Name | Eudesmin |
| Price: | $103 / 10mg |
| Catalog No.: | CN02792 |
| CAS No.: | 526-06-7 |
| Molecular Formula: | C22H26O6 |
| Molecular Weight: | 386.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The dry leaves of Haplophyllum perforatum Kar.et Kir. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(ccc1OC)[C@@H]1OC[C@@H]2[C@H]1CO[C@H]2c1ccc(c(c1)OC)OC |
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| Description | Eudesmin ((-)-Eudesmin) impairs adipogenic differentiation via inhibition of S6K1 signaling pathway. Eudesmin possesses diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities[1]. |
| Target | S6K1[1] |
| In Vitro | Treatment of mesenchymal stem cells (MSCs) with Eudesmin (20, 40, and 80μM) disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibits activation and nuclear translocation of S6K1. S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) is reduced upon Eudesmin treatment[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 517.3±50.0 °C at 760 mmHg |
| Flash Point | 209.8±30.0 °C |
| Exact Mass | 386.172943 |
| PSA | 55.38000 |
| LogP | 3.08 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Storage condition | 2-8°C |