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Tricetin
| Product Name | Tricetin |
| Price: | Inquiry |
| Catalog No.: | CN04333 |
| CAS No.: | 520-31-0 |
| Molecular Formula: | C15H10O7 |
| Molecular Weight: | 302.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Avena sativa |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway[1]. |
| In Vitro | Tricetin is mainly found in natural plants such as Ginkgo biloba L., Carica papaya L. and Murraya exotica L. Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of C. elegans. Tricetin has cytostatic properties and anti-metastatic activity of various solid tumors[1]. Pretreatment with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200 μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis[1]. Tricetin (80 μM; for 1, 2 and 4 h) markedly decreased the expressions of p-JNK and p-p38[1]. Cell Viability Assay Cell Line: SH-SY5Y cells Concentration: 20, 40, and 80 μM Incubation Time: Pretreatment for 4 h followed by 6-OHDA (200 μM) for 24 h Result: Significantly increased 6-OHDA-induced SH-SY5Y cells viability. Western Blot Analysis Cell Line: SH-SY5Y cells Concentration: 80 μM Incubation Time: 1, 2 and 4 h Result: Markedly decreased the expressions of p-JNK and p-p38. |
| Density | 1.763g/cm3 |
| Boiling Point | 721.7ºC at 760 mmHg |
| Flash Point | 277.9ºC |
| Exact Mass | 302.04300 |
| PSA | 131.36000 |
| LogP | 1.98800 |