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Cycleanine
| Product Name | Cycleanine |
| Price: | Inquiry |
| Catalog No.: | CN00750 |
| CAS No.: | 518-94-5 |
| Molecular Formula: | C38H42N2O6 |
| Molecular Weight: | 622.76 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Chondodendron tomentosum |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1c(OC)cc2c3c1Oc1ccc(cc1)CC1N(C)CCc4c1c(Oc1ccc(CC3N(CC2)C)cc1)c(c(c4)OC)OC |
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| Description | Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2]. |
| Target | L-type calcium channel |
| In Vitro | Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1]. Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2]. Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2]. Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2]. Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2]. Cell Cytotoxicity Assay[2] Cell Line: Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cells Concentration: 20 μM Incubation Time: 48 hours Result: Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively. Western Blot Analysis[2] Cell Line: Ovcar-8 cells Concentration: 20 μM Incubation Time: 24 hours Result: Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin. Apoptosis Analysis[2] Cell Line: Ovcar-8 cells Concentration: 20 μM Incubation Time: 48 hours Result: Caused a significant increase of the population of both early and late apoptotic cells. Cell Cycle Analysis[2] Cell Line: Ovcar-8 cells Concentration: 20 μM Incubation Time: 48 hours Result: Increased the percentage of Ovcar-8 cells in subG1. |
| In Vivo | Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 691.6±55.0 °C at 760 mmHg |
| Flash Point | 169.8±28.7 °C |
| Exact Mass | 622.304260 |
| PSA | 61.86000 |
| LogP | 3.96 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |