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Neoechinulin A
| Product Name | Neoechinulin A |
| Price: | Inquiry |
| Catalog No.: | CN01941 |
| CAS No.: | 51551-29-2 |
| Molecular Formula: | C19H21N3O2 |
| Molecular Weight: | 323.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | From Aspergillus chevalieri. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C=CC(c1[nH]c2c(c1C=C1NC(=O)C(NC1=O)C)cccc2)(C)C |
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| Description | Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2]. |
| In Vitro | Neoechinulin A (RAW264.7 macrophages; 3 hours; cells then stimulated with LPS (1 μg/mL) for 18 hours) suppresses PGE2, TNF-α, and IL-1β production in a dose-dependent manner[2]. Neoechinulin A can suppress the production of pro-inflammatory mediators and cytokines including NO, PGE2, TNF-α, and IL-1β. Further, it reduced the expression of iNOS and COX-2 in LPS-stimulated RAW264.7 macrophages by inhibiting the NF-κB and p38 MAPK signaling pathways[2]. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity[3]. |
| In Vivo | In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 655.7±55.0 °C at 760 mmHg |
| Flash Point | 350.4±31.5 °C |
| Exact Mass | 323.163391 |
| PSA | 73.99000 |
| LogP | 2.55 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |