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Sugiol
| Product Name | Sugiol |
| Price: | Inquiry |
| Catalog No.: | CN08615 |
| CAS No.: | 511-05-7 |
| Molecular Formula: | C20H28O2 |
| Molecular Weight: | 300.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Salvia yunnanensis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1]. |
| Target | ERK1 ERK2 p38 MAPK JNK1 JNK2 IL-1β |
| In Vitro | Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。 Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。 Western Blot Analysis[1] Cell Line: J774A.1 macrophages cells stimulated with LPS Concentration: 5 μM, 10 μM, 20 μM, and 30 μM Incubation Time: 30 min Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation. |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 437.2±45.0 °C at 760 mmHg |
| Flash Point | 186.4±21.3 °C |
| Exact Mass | 300.208923 |
| PSA | 37.30000 |
| LogP | 6.77 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |