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(-)-Licarin B
| Product Name | (-)-Licarin B |
| Price: | $146 / 20mg |
| Catalog No.: | CN02976 |
| CAS No.: | 51020-87-2 |
| Molecular Formula: | C20H20O4 |
| Molecular Weight: | 324.37 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | White powder |
| Source: | The seeds of Myristica fragrans Houtt. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C/C=C/c1cc2c(c(c1)OC)O[C@H]([C@@H]2C)c1ccc2c(c1)OCO2 |
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| Description | Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway[1][2][3]. |
| In Vitro | Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes[2]. Cell Viability Assay[1] Cell Line: 3T3-L1 cell. Concentration: 1-500 μM. Incubation Time: 48 h. Result: Did not cause significant cell death up to 500 μM concentration. Cell Viability Assay[1] Cell Line: 3T3-L1 cell. Concentration: 5 μM, 10 μM, 15 μM. Incubation Time: 8 days (replaced every 2 days). Result: LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 428.5±45.0 °C at 760 mmHg |
| Flash Point | 131.4±35.6 °C |
| Exact Mass | 324.136169 |
| PSA | 36.92000 |
| LogP | 5.08 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Storage condition | 2-8C |