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Convallatoxin
| Product Name | Convallatoxin |
| Price: | Inquiry |
| Catalog No.: | CN02290 |
| CAS No.: | 508-75-8 |
| Molecular Formula: | C29H42O10 |
| Molecular Weight: | 550.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The herbs of Convallaria majalis L. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | O=C[C@@]12CC[C@@H](C[C@@]2(O)CC[C@@H]2[C@@H]1CC[C@]1([C@]2(O)CC[C@@H]1C1=CC(=O)OC1)C)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O |
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| Description | Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties[1][2][3]. |
| In Vitro | Convallatoxin induces HaCaT cell necroptosis[4]. |
| In Vivo | Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis[4]. |
| Density | 1.41 g/cm3 |
| Boiling Point | 757.3ºC at 760 mmHg |
| Flash Point | 247.1ºC |
| Exact Mass | 550.27800 |
| PSA | 162.98000 |
| LogP | 0.75000 |