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Tumulosic acid
| Product Name | Tumulosic acid |
| Price: | $439 / 5mg |
| Catalog No.: | CN07135 |
| CAS No.: | 508-24-7 |
| Molecular Formula: | C31H50O4 |
| Molecular Weight: | 486.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Wolfiporia cocos |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(C(=C)CC[C@H]([C@H]1[C@H](O)C[C@@]2([C@]1(C)CCC1=C2CC[C@@H]2[C@]1(C)CC[C@@H](C2(C)C)O)C)C(=O)O)C |
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| Description | Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1]. |
| In Vitro | Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1]. Tumulosic acid decreases in LL-37 production in human keratinocytes[1]. Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1]. Western Blot Analysis[1] Cell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 1 μM and 10 μM Incubation Time: 23 h in the presence of 10 μM cycloheximide Result: Decreased LL-37 production in epidermal keratinocytes. |
| Exact Mass | 486.37100 |
| PSA | 77.76000 |
| LogP | 6.76060 |
| Storage condition | 2-8℃ |