Home
Products
Kawain
| Product Name | Kawain |
| Price: | $89 / 10mg |
| Catalog No.: | CN03843 |
| CAS No.: | 500-64-1 |
| Molecular Formula: | C14H14O3 |
| Molecular Weight: | 230.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The roots of Piper methysticum Forst |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COC1=CC(=O)O[C@H](C1)/C=C/c1ccccc1 |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4]. |
| Target | Na+, Ca2+ channel[1]. α4β2δ GABAA receptor[2]. |
| In Vitro | (+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM[2]. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF[4]. |
| In Vivo | (+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM[2]. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF[4]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 432.6±45.0 °C at 760 mmHg |
| Flash Point | 184.6±23.3 °C |
| Exact Mass | 230.094299 |
| PSA | 35.53000 |
| LogP | 1.69 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Storage condition | -20℃ |