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Estriol
| Product Name | Estriol |
| Price: | Inquiry |
| Catalog No.: | CN02514 |
| CAS No.: | 50-27-1 |
| Molecular Formula: | C18H24O3 |
| Molecular Weight: | 288.38 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The urine from pregnant horses. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1C[C@H]([C@@H]2O)O)C |
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| Description | Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.Target: Estrogen Receptor/ERRA recent study shows that estrogen (estrone, estradiol, and estriol) inhibits Alzheimer's disease-associated low-order Aβ oligomer formation, and among them, estriol shows the strongest in vitro activity [1]. In mPTEN+/- mice, estriol treatments resulted in a 187.54% gain in the relative ratio of uterine wet weight to body weight; estriol also increases the ratio to 176.88% in wild-type mice [2]. Estriol treatment (20 mg/kg ip), in vivo, sensitizes Kupffer cells to LPS via mechanisms dependent on an increase in CD14 by elevated portal blood endotoxin caused by increased gut permeability in rats; while one-half of the rats given estriol intraperitoneally 24 hours before an injection of a sublethal dose of LPS (5 mg/kg) died within 24 hours [3]. |
| Target | Human Endogenous Metabolite |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 469.0±45.0 °C at 760 mmHg |
| Flash Point | 220.8±23.3 °C |
| Exact Mass | 288.172546 |
| PSA | 60.69000 |
| LogP | 2.94 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Storage condition | -20°C Freezer |