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Hydrocortisone
| Product Name | Hydrocortisone |
| Price: | Inquiry |
| Catalog No.: | CN02525 |
| CAS No.: | 50-23-7 |
| Molecular Formula: | C21H30O5 |
| Molecular Weight: | 362.46 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | From a simple carbon source by recombinant Saccharomyces cerevisiae strains. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@H]1[C@H]2CCC2=CC(=O)CC[C@]12C |
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| Description | Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. |
| Target | Human Endogenous Metabolite |
| In Vitro | Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3]. |
| Cell Assay | Cells are plated on top of collagen IV-coated transwell chambers for six-well plates (24 mm diameter, membrane material: polyethylene terephthalate (PET), 0.4 μm pores, pore density 1.6×106 cm2) at densities of 2.5×104 cells cm2 per well. When they have reached confluence at day 5, the different experimental sets of cells are transferred to differentiation medium containing reduced amounts of FCS and treated with TNFα or hydrocortisone as indicated. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 566.5±50.0 °C at 760 mmHg |
| Flash Point | 310.4±26.6 °C |
| Exact Mass | 362.209320 |
| PSA | 94.83000 |
| LogP | 1.43 |
| Vapour Pressure | 0.0±3.5 mmHg at 25°C |