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Desoxypeganine
| Product Name | Desoxypeganine |
| Price: | Inquiry |
| Catalog No.: | CN00812 |
| CAS No.: | 495-59-0 |
| Molecular Formula: | C11H12N2 |
| Molecular Weight: | 172.23 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Peganum harmala |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C1CC2=Nc3c(CN2C1)cccc3 |
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| Description | Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research[1]. |
| Target | BChE:2 μM (IC50) AChE:17 μM (IC50) MAO-A:2 μM (IC50) |
| In Vivo | Desoxypeganine (10-30 mg/kg，灌胃，每天一次，连续 16 天) 剂量依赖性地降低乙醇摄入量和乙醇偏好[1]。 Animal Model: Female Alko alcohol (AA) rats (Thirty eight adult)[1] Dosage: 10, 20, 30 mg/kg Administration: Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days Result: Abolished ethanol preference. |
| Density | 1.23g/cm3 |
| Boiling Point | 311.6ºC at 760mmHg |
| Flash Point | 142.3ºC |
| Exact Mass | 172.10000 |
| PSA | 15.60000 |
| LogP | 1.69950 |