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Curcumol
| Product Name | Curcumol |
| Price: | $31 / 20mg |
| Catalog No.: | CN09526 |
| CAS No.: | 4871-97-0 |
| Molecular Formula: | C15H24O2 |
| Molecular Weight: | 236.35 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Curcuma longa L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC([C@@H]1CC23O[C@@]1(O)CC(=C)[C@@H]3CC[C@@H]2C)C |
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| Description | Curcumol is a sesquiterpene originally isolated from curcuma rhizomes; shows anticancer activities both in vitro and in vivo.IC50 value:Target: Anticancer natural compoundin vitro: Curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses [1]. Curcumol-induced growth inhibition correlated with apoptosis induction as evidenced by Annexin V staining, and cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in HSC-T6. Suppression of the NF-κB translocation via inhibition of IκB-α phosphorylation by the curcumol led to the inhibition of expression of NF-κB-regulated gene, e.g. Bcl-xL and Bcl-2, in a PI3K-dependent manner, which is upstream of NF-κB activation [2]. Curcumol exhibits an inhibitory effect on receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation with both bone marrow-derived macrophages and RAW264.7 cells in a dose-dependent manner [3].in vivo: Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/kg daily) significantly reduced tumor size without causing notable toxicity [1]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 334.5±42.0 °C at 760 mmHg |
| Flash Point | 134.7±22.1 °C |
| Exact Mass | 236.177628 |
| PSA | 29.46000 |
| LogP | 3.25 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |