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Butein
| Product Name | Butein |
| Price: | $54 / 10mg |
| Catalog No.: | CN05681 |
| CAS No.: | 487-52-5 |
| Molecular Formula: | C15H12O5 |
| Molecular Weight: | 272.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Yellow powder |
| Source: | The herbs of Broussonetia kazinoki. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Oc1ccc(c(c1)O)C(=O)/C=C/c1ccc(c(c1)O)O |
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| Description | Butein, a plant polyphenol isolated from Rhus verniciflua, inhibit the activation of protein tyrosine kinase and EGFR. target: EGFR [1]In vitro: 1) Butein inhibited the activation of AKT, extracellular signal-regulated kinase (ERKs) and p38 kinases in the presence of cisplatin.[2] 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.[2]3) Butein suppresses cell proliferation and enhances apoptosis in paclitaxel-resistant ovarian cancer cells.[3]4) Butein activates FOXO3a/p27kip1 pathway in ALL cell lines.[4]5) Butein inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50= 65 μM) and p60c-src(IC50= 65 μM)In vivo: 1) Butein in combination with cisplatin suppresses tumor growth and increases FoxO3a expression.[1] |
| Target | EGFR |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 560.9±50.0 °C at 760 mmHg |
| Flash Point | 307.1±26.6 °C |
| PSA | 17.07000 |
| LogP | 2.66 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Storage condition | -20°C |