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Phillyrin
| Product Name | Phillyrin |
| Price: | $23 / 20mg |
| Catalog No.: | CN02958 |
| CAS No.: | 487-41-2 |
| Molecular Formula: | C27H34O11 |
| Molecular Weight: | 534.56 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The fruits of Forsythia suspensa |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@@H](Oc2ccc(c(c2)OC)[C@H]2OC[C@H]3[C@@H]2CO[C@H]3c2ccc(c(c2)OC)OC)[C@@H]([C@H]([C@@H]1O)O)O |
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| Description | Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1]. |
| Target | CYP1A2; CYP2D1[1] |
| In Vitro | Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells[1]. Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes[1]. RT-PCR[1] Cell Line: Human HepG2 hepatocyte cells Concentration: 1 μM; 2.5 μM; 5 μM Incubation Time: 24 hours Result: Reduced FAS and SREBP-1c mRNA expression. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 730.4±60.0 °C at 760 mmHg |
| Flash Point | 395.5±32.9 °C |
| Exact Mass | 534.210083 |
| PSA | 145.53000 |
| LogP | 0.08 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |