Home
Products
Harman
| Product Name | Harman |
| Price: | Inquiry |
| Catalog No.: | CN01106 |
| CAS No.: | 486-84-0 |
| Molecular Formula: | C12H10N2 |
| Molecular Weight: | 182.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Rauvolfia verticillata |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Cc1nccc2c1[nH]c1c2cccc1 |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect[1][2][3][4]. |
| Target | hMAO-A:0.5 μM (IC50) MAO-B:5 μM (IC50) α2-adrenergic receptor:18 μM (IC50) I1-Imidazoline receptor:30 nM (IC50) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 386.9±22.0 °C at 760 mmHg |
| Flash Point | 176.2±13.6 °C |
| Exact Mass | 182.084396 |
| PSA | 28.68000 |
| LogP | 3.26 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |