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Daphnetin
| Product Name | Daphnetin |
| Price: | Inquiry |
| Catalog No.: | CN06292 |
| CAS No.: | 486-35-1 |
| Molecular Formula: | C9H6O4 |
| Molecular Weight: | 178.14 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Powder |
| Source: | The herbs of Daphne Korean Nakai |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=c1ccc2c(o1)c(O)c(cc2)O |
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| Description | Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative isolated from plants of the Genus Daphne, is a protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively[1][2]. Daphnetin (7,8-dihydroxycoumarin) is a secondary metabolite of plants used in folk medicine to counter inflammatory and allergic diseases, also has been clinically used in the treatment of coagulation disorders, rheumatoid arthritis with anti-malarian and anti-pyretic properties[3]. |
| Target | EGFR:7.67 μM (IC50) PKA:9.33 μM (IC50) PKC:25.01 μM (IC50) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 430.4±45.0 °C at 760 mmHg |
| Flash Point | 184.5±22.2 °C |
| Exact Mass | 178.026611 |
| PSA | 70.67000 |
| LogP | 0.77 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |