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N-Nornuciferine
| Product Name | N-Nornuciferine |
| Price: | $146 / 10mg |
| Catalog No.: | CN01056 |
| CAS No.: | 4846-19-9 |
| Molecular Formula: | C18H19NO2 |
| Molecular Weight: | 281.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The fruits of Piper nigrum |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc2CCN[C@H]3c2c(c1OC)c1ccccc1C3 |
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| Description | N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC50 and Ki of 3.76 and 2.34 μM, respectively. |
| Target | IC50: 3.76 μM (CYP2D6)[1] Ki: 2.34 μM (CYP2D6)[1] |
| In Vitro | The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent Ki values of 2.34 μM[1]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 446.4±45.0 °C at 760 mmHg |
| Flash Point | 182.8±18.2 °C |
| Exact Mass | 281.141571 |
| PSA | 30.49000 |
| LogP | 3.23 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Storage condition | 2-8℃ |