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RG108
| Product Name | RG108 |
| Price: | Inquiry |
| Catalog No.: | CN00144 |
| CAS No.: | 48208-26-0 |
| Molecular Formula: | C19H14N2O4 |
| Molecular Weight: | 334.33 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)[C@@H](N1C(=O)c2c(C1=O)cccc2)Cc1c[nH]c2c1cccc2 |
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| Description | RG108 is a non-nucleoside inhibitor of DNA methyltransferase with an IC50 of 115 nM. |
| Target | CpG methylase M.SssI:115 nM (IC50) |
| In Vitro | RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences[1]. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes[2]. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs[3]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 606.0±50.0 °C at 760 mmHg |
| Flash Point | 320.3±30.1 °C |
| Exact Mass | 334.095367 |
| PSA | 90.47000 |
| LogP | 3.33 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Storage condition | Store at RT |