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Isopimpinellin
| Product Name | Isopimpinellin |
| Price: | $77 / 20mg |
| Catalog No.: | CN06263 |
| CAS No.: | 482-27-9 |
| Molecular Formula: | C13H10O5 |
| Molecular Weight: | 246.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Yellow powder |
| Source: | The roots of Pimpinella saxifraga. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1c2ccc(=O)oc2c(c2c1cco2)OC |
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| Description | Isopimpinellin, an orally active compound isolated from the roots of Pimpinella saxifrage. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect[1]. |
| In Vivo | Isopimpinellin (oral gavage, 35-150 mg/kg) inhibits B[a]P-DNA adduct formation and DMBA–DNA adduct formation in SENCAR mice with skin tumor[1]. Animal Model: Female SENCAR mice (7-9 weeks of age) were fed AIN-76A semi-purified diet (Dyets, Bethlehem, PA) for 2 weeks prior to and during the study[1]. Dosage: 35–150 mg/kg. Administration: Oral gavage, suspended in 0.1 mL corn oil at 24 h and 2 h prior to topical treatment with [3H]B[a]P (200 nmol, 1 Ci/mmol) or [3H]DMBA (10 nmol, 10 Ci/mmol) (each in 0.2 mL acetone). Result: Significantly inhibited B[a]P-DNA adduct formation by 37 and 26%, respectively. Isopimpinellin (35, 70 and 150 mg/kg) blocked DMBA–DNA adduct formation by 23, 56 and 69%, respectively |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 448.7±45.0 °C at 760 mmHg |
| Flash Point | 225.1±28.7 °C |
| Exact Mass | 246.052826 |
| PSA | 61.81000 |
| LogP | 2.31 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Storage condition | 2-8°C |