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2',4',6'-Trihydroxyacetophenone
| Product Name | 2',4',6'-Trihydroxyacetophenone |
| Price: | Inquiry |
| Catalog No.: | CN03774 |
| CAS No.: | 480-66-0 |
| Molecular Formula: | C8H8O4 |
| Molecular Weight: | 168.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The barks of Albizia julibrissin |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=O)c1c(O)cc(cc1O)O |
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| Description | Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2]. |
| Target | Cholesterol 7α-hydroxylase[1], Mrp2[2] |
| In Vitro | Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level[1]. Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver[2]. |
| In Vivo | Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis[2]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 333.2±22.0 °C at 760 mmHg |
| Flash Point | 169.5±18.8 °C |
| Exact Mass | 168.042252 |
| PSA | 77.76000 |
| LogP | 2.07 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Storage condition | Refrigerator |