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Orobol
| Product Name | Orobol |
| Price: | Inquiry |
| Catalog No.: | CN05356 |
| CAS No.: | 480-23-9 |
| Molecular Formula: | C15H10O6 |
| Molecular Weight: | 286.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The herbs of Wisteria sinensis. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ)[1][2]. |
| In Vitro | Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon[2]. Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1[2]. |
| In Vivo | Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice[2]. Animal Model: HFD-induced obesity in C57BL/6J mice[2] Dosage: 10 mg/kg Administration: Intragastrically; daily for 23 weeks Result: Significantly reduced body weight by 17.3% compared to the HFD group. |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 616.1±55.0 °C at 760 mmHg |
| Flash Point | 239.5±25.0 °C |
| Exact Mass | 286.047729 |
| PSA | 111.13000 |
| LogP | 2.76 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |