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Aromadendrin
| Product Name | Aromadendrin |
| Price: | $176 / 5mg |
| Catalog No.: | CN05357 |
| CAS No.: | 480-20-6 |
| Molecular Formula: | C15H12O6 |
| Molecular Weight: | 288.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The barks of Eucalyptus calophylla |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Oc1ccc(cc1)[C@H]1Oc2cc(O)cc(c2C(=O)[C@@H]1O)O |
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| Description | Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1]. |
| Target | Apoptosis; Bcl-2; Bcl-xL[1] |
| In Vitro | Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1]. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1]. Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1]. Cell Proliferation Assay[1] Cell Line: Normal synoviocyte cells; RA-FLS cells Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time: 48 hours Result: Decreased the proliferation of RA-FLSs. Apoptosis Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Induced apoptosis in RA-FLSs. Western Blot Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 639.0±55.0 °C at 760 mmHg |
| Flash Point | 247.3±25.0 °C |
| Exact Mass | 288.063385 |
| PSA | 107.22000 |
| LogP | 2.42 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Storage condition | ?20°C |