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Dehydrocostus lactone
| Product Name | Dehydrocostus lactone |
| Price: | Inquiry |
| Catalog No.: | CN09426 |
| CAS No.: | 477-43-0 |
| Molecular Formula: | C15H18O2 |
| Molecular Weight: | 230.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Saussurea lappa |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C=C1C(=O)OC2C1CCC(=C)C1C2C(=C)CC1 |
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| Description | Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea lappa.IC50 value:Target:In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression.In vivo: Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo [3]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 383.7±42.0 °C at 760 mmHg |
| Flash Point | 161.2±25.3 °C |
| Exact Mass | 230.130676 |
| PSA | 26.30000 |
| LogP | 3.40 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Storage condition | room temp |