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NVP-ADW742
| Product Name | NVP-ADW742 |
| Price: | Inquiry |
| Catalog No.: | CN00145 |
| CAS No.: | 475488-23-4 |
| Molecular Formula: | C28H31N5O |
| Molecular Weight: | 453.58 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Nc1ncnc2c1c(cn2C1CC(C1)CN1CCCC1)c1cccc(c1)OCc1ccccc1 |
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| Description | NVP-ADW742(ADW742; GSK 552602A ) is an selective IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.IC50 value: 0.17 uM [1]Target: IGF-1Rin vitro: NVP-ADW742 exhibits a 6-fold greater selectivity for IGF-1R versus InsR with IC50 of 2.8 μM; minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR2, or Bcr-Abl p210 with IC50 greater than 5 μM. NVP-ADW742 significantly inhibits the serum-stimulated cell proliferation in a variety of tumor cell lines in dose-dependent manner, with IC50 values of 0.1-0.5 μM for the multiple myeloma (MM) cell lines, and the antitumor effects on MM cells can not be overcome by the co-culture with BMSCs. NVP-ADW742 also abrogates the responsiveness of tumor cells to IL-6 in the presence of serum [1]. Pretreatment of the H526 cell line with NVP-ADW742 inhibited IGF-IR signaling and growth with IC(50) values between 0.1 and 0.4 micro M [2].in vivo: Administration of NVP-ADW742 at 10 mg/kg twice daily significantly inhibits tumor growth, prolongs survival, and enhances the antitumor effect of cytotoxic chemotherapy melphalan in the mice model of diffuse MM [1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 677.5±55.0 °C at 760 mmHg |
| Flash Point | 363.5±31.5 °C |
| Exact Mass | 453.252869 |
| PSA | 69.20000 |
| LogP | 5.23 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Storage condition | -20°C |