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Glaucine
| Product Name | Glaucine |
| Price: | $351 / 10mg |
| Catalog No.: | CN01305 |
| CAS No.: | 475-81-0 |
| Molecular Formula: | C21H25NO4 |
| Molecular Weight: | 355.43 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The tubers of Corydalis yanhusuo |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc2c(cc1OC)C[C@H]1c3c2c(OC)c(OC)cc3CCN1C |
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| Description | Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities[1][2][3]. |
| Target | Ki: 3.4 µM (Phosphodiesterase 4 (PDE4))[1] α-adrenoceptor[1] Ca2+ channel[1] Dopamine D1/D2 receptors[2] |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 487.0±45.0 °C at 760 mmHg |
| Flash Point | 140.2±25.9 °C |
| Exact Mass | 355.178345 |
| PSA | 40.16000 |
| LogP | 3.86 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |